张伟

生物学 / 专业

基本信息

  • 张伟 / 男 / 33岁
  • CET-6
  • 网络技术三级

联系方式

技能点

微信二维码

教育经历

  • 陕西师范大学 - 细胞生物学专业（博士）

    在读期间发表论文8篇(2篇一作)；获陕西师范大学积学奖3次。

  • 赣南师范大学 - 化学生物学专业（硕士）

    在读期间发表论文3篇(2篇一作，导师一作本人二作1篇)；获学业奖学金2次；校级优秀毕业生。

  • 临沂大学 - 生物技术专业（本科）

    2010年，省级英语口语三级；2012-2013年，校优秀舍长。

参与项目

  • [经历1] 细胞外基质蛋白him2/fbln8与心脏心肌心血管发育构建的遗传机理研究

    • 参与实验工作

  • [经历2] 细胞外基质蛋白him1/fbln6与心脏发育构建的遗传机理研究

    • 参与实验工作

  • [经历3] 心房肥大导致心猝死的FKBP-RyR复合体相关基因的细胞机制研究

    • 参与实验工作

科研成果

  • Molecular Mechanism on Autophagy Associated Cardiovascular Dysfunction in Drosophila melanogaster pdf

    • Frontiers in Cell and Developmental Biology
    • doi: 10.3389/fcell.2025.1512341
    • Wei Zhang, Rong Zhou, Xinjuan Lei, Mofei Wang, Qinchun Duan, Yuanlin Miao, Tingting Zhang, Xinjie Li, Zutong Zhang, Liyang Wang, Odell D Jones, Mengmeng Xu, Joseph Bryant, Jianjie Ma, Yingli Liu and Xuehong Xu.
    • This review evaluates the functional significance of autophagy in the heart, particularly in the context of Drosophila, in relation to mTORC-associated autophagy and the axis of Atg2-AMPK/Sirt1/PGC-1α pathways. The conservation of autophagy underscores the value of Drosophila as model for understanding broader mechanisms of autophagy across species, which deepens our understanding of autophagy's role in cardiovascular function and a theoretical foundation for the potential application in agricultural pest control.
    • 陕西师范大学

  • Autophagy in High-Fat Diet and Streptozotocin-Induced Metabolic Cardiomyopathy: Mechanisms and Therapeutic Implications pdf

    • International Journal of Molecular Sciences
    • doi: 10.3390/ijms26041668
    • Zhou, Rong, Zutong Zhang, Xinjie Li, Qinchun Duan, Yuanlin Miao, Tingting Zhang, Mofei Wang, Jiali Li, Wei Zhang, Liyang Wang, Odell D. Jones, Mengmeng Xu, Yingli Liu and Xuehong Xu.
    • Despite recent advances, the precise mechanisms underlying autophagy in this context remain poorly understood. A deeper understanding of autophagy’s regulatory networks, particularly involving these critical genes and proteins, may lead to novel therapeutic approaches for treating metabolic cardiomyopathy.
    • 陕西师范大学

  • A Protocol for Immunohistochemistry and RNA In-situ Distribution within Early Drosophila Embryo pdf

    • Journal of visualized experiments : JoVE
    • doi: 10.3791/61776
    • Wei Zhang, Xinjuan Lei, Xin Zhou, Boling He, Liqin Xiao, Huimin Yue, Shulin Wang, Yuting Sun, Yajun Wu, Liyang Wang, George Ghartey-Kwansah, Odell D. Jones, Joseph L. Bryant, MengMeng Xu, Jianjie Ma and Xuehong Xu.
    • Here, we describe a protocol for detection and localization of Drosophila embryo protein and RNA from collection to pre-embedding and embedding, immunostaining, and mRNA in situ hybridization.
    • 陕西师范大学

  • Cardiac-Specific Expression of Cre Recombinase Leads to Age-Related Cardiac Dysfunction Associated with Tumor-like Growth of Atrial Cardiomyocyte and Ventricular Fibrosis and Ferroptosis pdf

    • International journal of molecular sciences
    • doi: 10.3390/ijms24043094
    • Zhongguang Li, Qinchun Duan, Ying Cui, Odell D Jones, Danyang Shao, Jianfei Zhang, Yuru Gao, Xixi Cao, Shulin Wang, Jiali Li, Xinjuan Lei, Wei Zhang, Liyang Wang, Xin Zhou, Mengmeng Xu, Yingli Liu, Jianjie Ma and Xuehong Xu.
    • Our study suggests that αMHC-Cre mouse models are effective in young mice, but not in old mice. Researchers need to be particularly careful when using αMHC-Cre mouse model to interpret those phenotypic impacts of gene responses. As the Cre-associated cardiac pathology matched mostly to that of the patients, the model could also be employed for investigating age-related cardiac dysfunction.
    • 陕西师范大学

  • Dynamics expression of DmFKBP12/Calstabin during embryonic early development of Drosophila melanogaster pdf

    • Cell & Bioscience
    • doi: 10.1186/s13578-019-0270-6
    • Rui Feng, Xin Zhou, Wei Zhang, Tao Pu, Yuting Sun, Rong Yang, Dan Wang, Xiaofei Zhang, Yingfeng Gao, Zhenlu Cai, Yu Liang, Qiuxia Yu, Yajun Wu, Xinjuan Lei, Zhijia Liang, Odell Jones, Liyang Wang, Mengmeng Xu, Yanping Sun, William B Isaacs, Jianjie Ma and Xuehong Xu.
    • As a critical regulator of the DmRyR-FKBP complex, DmFKBP12 expression in Drosophila fluctuates temporally and geographically with the formation of organ systems. These finding indicate that DmFKBP12 and RyR associated calcium signaling plays an essential role in the successful development of Drosophila melanogaster. Further study on the differences between mammalian RyR-FKBP12 and Drosophila DmRyR-FKBP12 can be exploited to develop safe pesticides.
    • 陕西师范大学

  • Nonalcoholic fatty liver disease experiences accumulation of hepatic liquid crystal associated with increasing lipophagy pdf

    • Cell & Bioscience
    • doi: 10.1186/s13578-020-00414-2
    • Liyang Wang, MengMeng Xu, Odell D. Jones, Zhongguang Li, Yu Liang, Qiuxia Yu, Jiali Li, Yajun Wu, Xinjuan Lei, Boling He, Huimin Yue, Liqin Xiao, Rong Zhou, Wei Zhang, Xin Zhou, Yuhui Zhang, Joseph L. Bryant, Jianjie Ma, Yingli Liu and Xuehong Xu.
    • Increasing concentrations of amphiphilic lipids in HLDs favors organization into alternating hydrophilic and hydrophobic layers, which present as LC-HLDs. Thus, evaluating the extent of liquid crystallization with phase transition in HLDs of NAFLD patients may reveal disease severity and predict impending liver damage.
    • 陕西师范大学

  • A systematic comparison of exercise training protocols on animal models of cardiovascular capacity pdf

    • Life sciences
    • doi: 10.1016/j.lfs.2018.12.001
    • Rui Feng, Liyang Wang, Zhonguang Li, Rong Yang, Yu Liang, Yuting Sun, Qiuxia Yu, George Ghartey-Kwansah, Yanping Sun, Yajun Wu, Wei Zhang, Xin Zhou, Mengmeng Xu, Joseph Bryant, Guifang Yan, William Isaacs, Jianjie Ma and Xuehong Xu.
    • Systematic organization of existent protocols and this new system of defining exercise duration will allow for a more solid framework from which researchers can extrapolate animal model data to clinical application.
    • 陕西师范大学

  • COVID-19 疫情分子生物学特性及其血管疾病高危的细胞分子机理 pdf

    • 科学与财富
    • 肖丽琴, 岳慧敏, 何博聆, 雷新娟, 吴亚君, 张伟, 王李阳, 李忠光, 徐学红.
    • 本文就中国及世界范围内的疫情医学生物学研究现状进行了分析，对新冠肺炎的发展进行了预测，以期为抗疫的最终完成和未来可能的下一个疫情提供有价值的信息。
    • 陕西师范大学

  • 医学分子生物学CRISPR基因编辑与社会法规的进步与完善 pdf

    • 医学与社会
    • 10.13723/j.yxysh.2019.06.009
    • 杨蓉, 梁瑜, 于秋霞, 吴亚君, 雷新娟, 孙渝婷, 王丹, 张伟, 周鑫, 李忠光, 王李阳, MengMeng Xu, William Isaacs, Jianjie Ma, 徐学红.
    • CRISPR精准基因编辑和干细胞技术的巨大科研前景和商业价值，可能会带来一系列的问题。卫生主管部门应借鉴国际上相关做法，置顶科学研究伦理道德的相关政策法规，使中国在医学分子生物学领域做出应有的贡献。
    • 陕西师范大学

  • Are dominant plant species more susceptible to leaf-mining insects? A case study at Saihanwula Nature Reserve, China pdf

    • Ecology and evolution
    • doi: 10.1002/ece3.4284
    • Xiaohua Dai, Cehngpeng Long, Jiasheng Xu, Qingyun Guo, Wei Zhang, Zhihong ZHang and Bater.
    • Dominant species significantly affect interspecific relationships, community structure, and ecosystem function. In the field, dominant species are often identified by their high importance values. Selective foraging on dominant species is a common phenomenon in ecology. Our hypothesis is that dominant plant groups with high importance values are more susceptible to leaf-mining insects at the regional level. Here, we used the Saihanwula National Nature Reserve as a case study to examine the presence-absence patterns of leaf-mining insects on different plants in a forest-grassland ecotone in Northeast China. We identified the following patterns: (1) After phylogenetic correction, plants with high importance values are more likely to host leafminers at the species, genus, or family level. (2) Other factors including phylogenetic isolation, life form, water ecotype, and phytogeographical type of plants have different influences on the relationship between plant dominance and leafminer presence. In summary, the importance value is a valid predictor of the presence of consumers, even when we consider the effects of plant phylogeny and other plant attributes. Dominant plant groups are large and susceptible targets of leaf-mining insects. The consistent leaf-mining distribution pattern across different countries, vegetation types, and plant taxa can be explained by the "species-area relationship" or the "plant apparency hypothesis."
    • 赣南师范大学

  • Global pattern of plant utilization across different organisms: Does plant apparency or plant phylogeny matter? pdf

    • Ecology and evolution
    • doi: 10.1002/ece3.2882
    • Xiaohua Dai, Wei Zhang, Jiasheng Xu, Kevin J Duffy and Qingyun Guo.
    • The present study is the first to consider human and nonhuman consumers together to reveal several general patterns of plant utilization. We provide evidence that at a global scale, plant apparency and phylogenetic isolation can be important predictors of plant utilization and consumer diversity.
    • 赣南师范大学

  • 不同颜色色板对脐橙果园昆虫的诱集效果 pdf

    • 北方园艺
    • 张伟, 徐家生, 戴小华, 郭青云, 李国胜, 周芳.
    • 以脐橙果园内昆虫为调查对象,于2014年12月至2015年11月使用紫色、灰色、粉色、蓝色、青色、绿色、黄色、红色、白色和黑色等10种不同颜色的色板对脐橙果园内的昆虫进行诱集,研究了脐橙果园内昆虫群落的组成以及昆虫对不同颜色的趋向性。
    • 赣南师范大学

  • 圆形分布统计的江西省柑橘病虫害时间格局分析 pdf

    • 赣南师范学院学报
    • 10.13698/j.cnki.cn36-1037/c.2014.06.014
    • 张伟, 戴小华, 徐家生, 王飞.
    • 虫害的发生呈现出不同的月份虫害在不同地区发生程度不同。圆形分布统计可用于病虫害及其天敌的昼夜节律和季节节律研虫害综合防治提供理论基础。
    • 赣南师范大学

自我评价/期望

  • 动手能力强👍，参与实验室的仪器设备安装和维护（比如-20℃冰箱维修、体式显微镜维修、排气扇维修更换、空调保养、网络维护和水管维修等）。
  • 运动不多，跳远还行，喜欢City Walk，喜欢在路上。
  • “道阻且长，行则将至”，脚踏实地做事。